期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 131, 期 5, 页码 1105-1109出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2010.350
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资金
- Spanish Ministry of Science and Innovation [SAF 2008-00357]
- Generalitat de Catalunya'' Departments of Health and Universities and Innovation
- National Natural Science Foundation of China [30771196, 30800990]
- Medical Research Council [G0000934]
- Wellcome Trust [068545/Z/02]
- UK Medical Research Council [G0601387]
- British Skin Foundation [1006]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Tokai University School of Medicine Research Aid
- ADIPSO (Italian Association for the Defence of Psoriasis Patients)
- Dermatology Foundation
- Academy of Finland
- Sigrid Juselius Foundation
- Centre National de Genotypage
- National Institutes of Health [R01AR42742, R01AR050511, R01AR054966, R01 AR050266]
- Ann Arbor Veteran Affairs Hospital
- Irish Health Research Board and Science Foundation, Ireland
- MRC [G0000934, G0601387] Funding Source: UKRI
- Grants-in-Aid for Scientific Research [19101008, 23390191] Funding Source: KAKEN
- Medical Research Council [G0601387, G0000934] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0507-10379] Funding Source: researchfish
A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.
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