期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 131, 期 1, 页码 141-149出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2010.259
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资金
- NIH [AR049288, AI060707]
- Procter Gamble Company
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K08AI060707] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR049288] Funding Source: NIH RePORTER
The NF-kappa B pathway performs pivotal roles in diverse physiological processes such as immunity, inflammation, proliferation, and apoptosis. NF-kappa B is kept inactive in the cytoplasm through association with inhibitors (I kappa B), and translocates to the nucleus to activate its target genes after the I kappa Bs are phosphorylated and degraded. Here, we demonstrate that loss of function of SHANK-associated RH domain interacting protein (SHARPIN) leads to activation of NF-kappa B signaling in skin, resulting in the development of an idiopathic hypereosinophilic syndrome (IHES) with eosinophilic dermatitis in C57BL/KaLawRij-Sharpin(cpdm) /RijSunJ mice, and clonal expansion of B-1 B cells and CD3(+)CD4(-)CD8(-) T cells. Transcription profiling in skin revealed constitutive activation of classical NF-kappa B pathways, predominantly by overexpressed members of IL1 family. Compound-null mutants for both the IL1 receptor accessory protein (Il1rap(tm1Roml)) and SHARPIN (Sharpin(cpdm)) resulted in mice having decreased skin disease severity. Inhibition of I kappa BA degradation by the proteasome inhibitor bortezomib alleviated the dermatitis in Sharpin(cpdm) mice. These results indicate that absence of SHARPIN causes IHES with eosinophilic dermatitis by NF-kappa B activation, and bortezomib may be an effective treatment for skin problems of IHES.
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