期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 130, 期 1, 页码 28-37出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2009.177
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资金
- Melanoma Research Foundation [93-032-13]
Despite years of research, there has been little improvement in survival for patients with disseminated melanoma. Recent work has identified mutations in BRAF and NRAS, leading to constitutive mitogen-activated protein kinase (MAPK) pathway as well as constitutive activity in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway, as being critical events in melanoma growth and progression. In the current review, we discuss how these complex mutational and signaling profiles can be understood using a network biology approach, and suggest how an understanding of the key signaling nodes involved in progression and survival will lead to improvements in melanoma therapy.
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