期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 130, 期 12, 页码 2752-2759出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2010.223
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资金
- The Netherlands Organization for Scientific Research (NWO) [VIDI 917.76.365]
- Landsteiner Foundation for Blood Transfusion Research (LSBR) [0414F]
- Innsbruck Medical University [MFI-9442]
- Austrian Science Fund [FWF-21487]
- Austrian Science Fund (FWF) [P 21487] Funding Source: researchfish
The relative roles of Langerhans cells (LC), dermal dendritic cells (DC), and, in particular, the recently discovered Langerin(+) dermal DC subset in the induction and control of contact hypersensitivity (CHS) responses remain controversial. Using an inducible mouse model, in which LC and other Langerin(+) DC can be depleted by injection of diphtheria toxin, we previously reported impaired transport of topically applied antigen to draining lymph nodes and reduced CHS in the absence of all Langerin(+) skin DC. In this study, we demonstrate that mice with a selective depletion of LC exhibit attenuated CHS only upon sensitization with a low hapten dose but not with a high hapten dose. In contrast, when painting a higher concentration of hapten onto the skin, which leads to increased antigen dissemination into the dermis, CHS is still diminished in mice lacking all Langerin(+) skin DC. Taken together, these data suggest that the magnitude of a CHS reaction depends on the number of skin DC, which have access to the hapten, rather than on the presence or absence of a particular skin DC population. LC and (Langerin(+)) dermal DC thus seem to have a redundant function in regulating CHS.
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