期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 129, 期 6, 页码 1339-1350出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2009.59
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资金
- Wellcome Trust, NIH
- NIHR Comprehensive Biomedical Research Centre Guy's and St Thomas' Hospital
- King's College London
- Medical Research Council UK
- SIDeMaST fellowship award
- Dunhill Medical Trust
- MRC [G0601387] Funding Source: UKRI
- Medical Research Council [G0601387] Funding Source: researchfish
Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis. Journal of Investigative Dermatology (2009) 129, 1339-1350; doi:10.1038/jid.2009.59; published online 26 March 2009
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