期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 129, 期 3, 页码 543-552出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2008.413
关键词
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类别
资金
- The British Skin Foundation
- The National Eczema Society
- The Medical Research Council [G0700314]
- A* STAR, Singapore
- The Newcastle Healthcare Charity
- Action Medical Research
- The British Society for Paediatric Dermatology
- Wellcome Trust
- MRC [G0700314] Funding Source: UKRI
- Medical Research Council [G0700314] Funding Source: researchfish
Multiple genetic as well as environmental factors interact in the pathogenesis of eczema. Increased understanding of genetic predisposition in atopy and eczema has directed interest toward key pathogenic mechanisms including skin barrier dysfunction. This review provides a succinct update on the current state of knowledge regarding eczema genetics. We discuss the relevance of loss-of-function mutations in the filaggrin gene within the context of other candidate gene studies and suggest possible applications for future research. Knowledge of genetic factors in eczema may translate into a clearer understanding of pathogenic mechanisms and hence more focused therapeutic strategies, but this remains at present a distant possibility.
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