期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 129, 期 3, 页码 531-535出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2008.440
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Pruritus in eczema and other inflammatory skin diseases is an unsolved problem. Recent findings strongly indicate that histamine is not the only mediator of pruritus. Subtypes of the transient receptor potential (TRP) ion channel superfamily are expressed by sensory nerves, keratinocytes, and certain leukocytes. Temperature, pH changes, and certain toxins activate TRPs. new evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus.
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