期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 128, 期 8, 页码 1950-1955出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2008.52
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资金
- NIAID NIH HHS [K08 AI076631-01, K08 AI076631] Funding Source: Medline
- NIAMS NIH HHS [K08 AR651092, R0I-AR4407] Funding Source: Medline
The mechanism of skin allograft rejection has been thought to require presentation of graft antigen by resident epidermal Langerhans cells (LCs). We have previously engineered mice that have a selective and constitutive absence of epidermal LCs. By using donor skin from these LC-deficient mice, we show that LCs are not required for rejection of major (FVB-->B6) or minor (H-Y, male-->female on B6 background) antigen-mismatched skin grafts. On the FVB background, where H-Y mismatched grafts are normally maintained indefinitely, grafts lacking LCs are efficiently rejected. Thus, LCs in the donor graft are required for long-term skin engraftment, which supports a regulatory role for LCs in skin graft acceptance.
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