期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 41, 期 5, 页码 1437-1444出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0300060513497560
关键词
Nonsmall cell lung cancer; serum; microRNA; microRNA-210; prognostic significance
资金
- Development of Science and Technology Plan Projects of Jilin [2012Z019]
Objective To investigate the levels of microRNA-210 (miR-210) in the serum of patients with nonsmall-cell lung cancer (NSCLC) and to determine whether there was a correlation with the prognosis of NSCLC patients following cisplatin-based chemotherapy. Methods Quantitative real-time reverse transcription-polymerase chain reaction was used to measure the serum levels of miR-210 in patients with NSCLC and healthy age-matched control subjects. Correlations between serum miR-210 levels and clinicopathological factors and prognosis were investigated. Results Serum miR-210 was significantly upregulated in 60 patients with NSCLC compared with 30 healthy control subjects. Higher serum miR-210 levels were significantly correlated with the clinical stage and the presence of regional lymph node metastasis in patients with NSCLC. Serum miR-210 levels in patients that achieved a partial response following cisplatin-based chemotherapy were significantly lower than in patients with stable or progressive disease, and were similar to those in healthy control subjects. Conclusions These findings suggest that serum miR-210 levels might be a novel diagnostic and prognostic marker of NSCLC.
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