期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 40, 期 2, 页码 426-435出版社
FIELD HOUSE PUBLISHING LLP
DOI: 10.1177/147323001204000204
关键词
MULTIPLE DRUG RESISTANCE (MDR); SIGNAL TRANSDUCTION PATHWAY; P-GLYCOPROTEIN; ABCB1; CANCER
资金
- Science and Technology Commission of Shanghai Municipality [10ZR1427400, 07ZR14111, 10140902600]
- Shanghai Municipal Education Commission [09YZ132]
- Shanghai Third Leading Academic Discipline Project [S30302]
Multiple drug resistance (MDR), defined as the ability of tumour cells to survive exposure to many chemotherapeutic agents, is a major cause of treatment failure in human cancers. The membrane transporter P-glycoprotein (Pgp, encoded by the ABCB1 [adenosine triphosphate-binding cassette, subfamily B, member 1] gene) is the main mechanism for decreased intracellular drug accumulation in human MDR cancer. ABCB1/Pgp-mediated MDR involves several signal transduction pathways and transcription factors. Activation of these signal transduction pathways influences the prognosis of MDR human cancer. Signalling pathways involved in ABCB1/Pgp-mediated MDR include the mitogen-activated protein kinase (MAPK), c-Jun NH2-terminal kinase (JNK), p38, cyclic adenosine monophosphate-dependent protein kinase, phosphatidylinositol 3-kinase and protein kinase C signalling pathways. This review summarizes the biological characteristics, target points and signalling cascade mediators of these pathways. Drugs targeted against these pathways may provide new therapies for treatment of ABCB1/Pgp-mediated MDR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据