Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem with NUTRIOSE (R), a Soluble Fibre with Prebiotic Properties, May Be Beneficial for Health

OBJECTIVES: The prebiotic potential of NUTRIOSE (R) - a sugar-free, digestion-resistant dextrin - was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively. METHODS: In study 1, the effect on colonic bacteria of NUTRIOSE (R) 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE (R) 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis. RESULTS: NUTRIOSE (R) increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased beta-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE (R) consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose. CONCLUSIONS: According to commonly accepted definitions, NUTRIOSE (R) is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort.