期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 39, 期 5, 页码 1908-1916出版社
FIELD HOUSE PUBLISHING LLP
DOI: 10.1177/147323001103900535
关键词
HUMAN CARDIAC SODIUM CHANNEL; SCN5A GENE; H558R; POLYMORPHISM; ATRIAL FIBRILLATION
资金
- National Natural Science Foundation of China [30771863]
- Natural Science Foundation of Heilongjiang Province of China [D2005-09]
- Special Funds for Technological Innovation Research Projects of Harbin [RC2008XK004039]
- Laboratory of Myocardial Ischaemia Mechanism and Treatment (Harbin Medical University)
- Ministry of Education of China [KF201011]
- Research Subjects of Department of Public Health of Heilongjiang Province [2010-358]
Atrial fibrillation (AF) is one of the most common sustained cardiac arrhythmias and its prevalence is increasing worldwide in line with the growing elderly population. Many single nucleotide polymorphisms and mutations are associated with AF, including the common loss-of-function histidine-558-to-arginine (H558R) polymorphism of the human cardiac sodium channel, voltage-gated, type V, a subunit (encoded by the SCN5A gene). The H558R polymorphism results from the T-C transition in the SCN5A gene. This study recruited 135 patients with AF and 296 healthy controls to scan for and perform targeted genotyping of the H558R polymorphism of the SCN5A gene. Logistic regression analysis showed that the TC and CC genotypes (i.e. genotypes that result in the R558 polymorphism) were significantly associated with an increased risk of developing AE The R558 polymorphism conferred an odds ratio for AF of 3.451 (95% confidence interval 1.718, 6.931). In conclusion, this study provided evidence for the role of the H558R polymorphism of the SCN5A gene in increasing the susceptibility to AF.
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