期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 39, 期 5, 页码 1783-1797出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/147323001103900521
关键词
ACUTE KIDNEY INJURY; RATS; ELECTROACUPUNCTURE; LIPOPOLYSACCHARIDE; INFLAMMATORY RESPONSE; CYTOKINE; NITRITE; NUCLEAR FACTOR kappa B
资金
- Outstanding Youth Science Foundation [JC200716]
- Education Bureau of Heilongjiang Province of China [1152hz33]
This study investigated the effect of electroacupuncture pretreatment on the lipopolysaccharide (LPS)-induced inflammatory response and on acute kidney injury in adult male pathogen-free Wistar rats. Rats received electroacupuncture at the Zusanli (ST36) and Neiguan (PC6) acupoints, or electrical stimulation at sham points, for 30 min before stimulation with either 5 mg/kg LPS intravenously or normal saline. Plasma cytokines, plasma nitrite, renal inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-kappa B) activity were assessed 240 min after LPS or normal saline injection. Blood urea nitrogen (BUN), creatinine (Cr) and histopathological score for renal tubular damage were also measured. Electroacupuncture pretreatment significantly decreased LPS-induced plasma tumour necrosis factor-a and interleukin (IL)-1 beta, increased plasma IL-10, and decreased plasma nitrite, renal iNOS and NF-kappa B activity. It also significantly decreased LPS-induced BUN, Cr and the renal histopathological score. These findings suggest that electroacupuncture pretreatment at the ST36 and PC6 acupoints attenuated the LPS-induced inflammatory response and mitigated acute kidney injury.
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