期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 37, 期 3, 页码 892-898出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/147323000903700335
关键词
SYSTEMIC LUPUS ERYTHEMATOSUS; LUPUS NEPHRITIS; PROTEINURIA; RENAL FUNCTION; ANGIOTENSIN-CONVERTING ENZYME INHIBITOR (ACEI); ANGIOTENSIN II RECEPTOR BLOCKER (ARB); LOSARTAN
Although the effects of angiotensin II receptor blockers (ARBs) on non-diabetic glomerulonephritis have been reported, studies of their effects on collagen-vascular diseases, particularly lupus nephritis, are limited. In this retrospective, observational study, systemic lupus erythematosus (SLE) patients (n = 7) with lupus nephritis and uncontrolled proteinuria were treated with an angiotensin-converting enzyme inhibitor followed by the ARB losartan (25 - 50 mg/day). Urinary protein excretion and renal function were evaluated. After 12 months of losartan, mean urinary protein excretion decreased significantly by 84.8%. Mean systolic and diastolic blood pressures also decreased significantly during the 12 months of losartan treatment, although not in normotensive patients. Complement 4, total complement activity and anti-dsDNA antibody levels, which are indices of SLE activity, and serum creatinine levels, which is an index of renal function, showed no change in response to losartan treatment. A more extensive evaluation of the effects of ARBs in patients with lupus nephritis and poorly controlled proteinuria is required.
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