期刊
JOURNAL OF INTERNAL MEDICINE
卷 273, 期 6, 页码 602-621出版社
WILEY
DOI: 10.1111/joim.12037
关键词
Alzheimer's disease; MRI; sensitivity; specificity; tocopherols; tocotrienols
资金
- InnoMed
- European Union [FP6-2004-LIFESCIHEALTH-5]
- Karolinska Institutet (Sweden)
- Strategic Research Programme in Neuroscience StratNeuro at Karolinska Institutet
- Hjarnfonden
- Swedish Brain Power
- Stockholm Medical Image Laboratory and Education (SMILE)
- Swedish foundation Ragnhild och Einar Lundstrooms-Minne-Lindhes
- Swedish foundation Stohnes-Stiftelse
- Swedish foundation Gamla-Tjanarinnor
- Academy of Finland Health Research Council
- Perugia University (Italy)
- NIHR Biomedical Research Centre for Mental Health at the South London
- Maudsley NHS Foundation Trust
- Institute of Psychiatry, Kings College London
- Regione Umbria, Italy
- University of Eastern Finland for UEFBRAIN
- Alzheimers Research UK [ARUK-EXT2013-4] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10053] Funding Source: researchfish
- Novo Nordisk Fonden [NNF11OC1014884, NNF12OC1016402] Funding Source: researchfish
Background The aim of this study was to evaluate the accuracy of combined structural magnetic resonance imaging (MRI) measures and plasma levels of vitamin E forms, including all eight natural vitamin E congeners (four tocopherols and four tocotrienols) and markers of vitamin E oxidative/nitrosative damage, in differentiating individuals with Alzheimer's disease (AD) and mild cognitive impairment (MCI) from cognitively intact control (CTL) subjects. Methods Overall, 81 patients with AD, 86 with MCI and 86 CTL individuals were enrolled from the longitudinal multicentre AddNeuroMed study. MRI and plasma vitamin E data were acquired at baseline. MRI scans were analysed using Freesurfer, an automated segmentation scheme which generates regional volume and cortical thickness measures. Orthogonal partial least squares to latent structures (OPLS), a multivariate data analysis technique, was used to analyse MRI and vitamin E measures in relation to AD and MCI diagnosis. Results The joint evaluation of MRI and plasma vitamin E measures enhanced the accuracy of differentiating individuals with AD and MCI from CTL subjects: 98.2% (sensitivity 98.8%, specificity 97.7%) for AD versus CTL, and 90.7% (sensitivity 91.8%, specificity 89.5%) for MCI versus CTL. This combination of measures also identified 85% of individuals with MCI who converted to clinical AD at follow-up after 1year. Conclusions Plasma levels of tocopherols and tocotrienols together with automated MRI measures can help to differentiate AD and MCI patients from CTL subjects, and to prospectively predict MCI conversion into AD. Our results suggest the potential role of nutritional biomarkers detected in plasmatocopherols and tocotrienolsas indirect indicators of AD pathology, and the utility of a multimodality approach.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据