An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment

Spulber G, Simmons A, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Wahlund L-O, Westman E (University Hospital of Kuopio, Kuopio, Finland; Karolinska Institutet, Stockholm, Sweden; Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health, London, UK; University of Perugia, Perugia, Italy; University of Toulouse, Toulouse, France; Aristotle University of Thessaloniki, Thessaloniki, Greece; Medical University of Lodz, Lodz, Poland; Karolinska Institutet, Stockholm, Sweden). An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment. J Intern Med 2013; 273: 396-409. Background Structural magnetic resonance imaging (MRI) is sensitive to neurodegeneration and can be used to estimate the risk of converting to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Brain changes in AD and prodromal AD involve a pattern of widespread atrophy. The use of multivariate analysis algorithms could enable the development of diagnostic tools based on structural MRI data. In this study, we investigated the possibility of combining multiple MRI features in the form of a severity index. Methods We used baseline MRI scans from two large multicentre cohorts (AddNeuroMed and ADNI). On the basis of volumetric and cortical thickness measures at baseline with AD cases and healthy control (CTL) subjects as training sets, we generated an MRI-based severity index using the method of orthogonal projection to latent structures (OPLS). The severity index tends to be close to 1 for AD patients and 0 for CTL subjects. Values above 0.5 indicate a more AD-like pattern. The index was then estimated for subjects with MCI, and the accuracy of classification was investigated. Results Based on the data at follow-up, 173 subjects converted to AD, of whom 112 (64.7%) were classified as AD-like and 61 (35.3%) as CTL-like. Conclusion We found that joint evaluation of multiple brain regions provided accurate discrimination between progressive and stable MCI, with better performance than hippocampal volume alone, or a limited set of features. A major challenge is still to determine optimal cut-off points for such parameters and to compare their relative reliability.