Current controversies in the use of haemoglobin A1c

Hare MJL, Shaw JE, Zimmet PZ (Baker IDI Heart and Diabetes Institute, Melbourne, Vic.; and Monash University, Melbourne, Vic.; Australia). Current controversies in the use of haemoglobin A1c (Review). J Intern Med 2012; 271: 227236. Haemoglobin A1c (HbA1c) has recently been adopted by the World Health Organization into its recommended criteria for diabetes diagnosis. Much debate continues regarding the relative benefits and potential disadvantages surrounding the use of HbA1c for this purpose. There is a lack of consensus as to whether this alteration to the definition of diabetes is a step forward or whether it could add further confusion and ambiguity to the debate on themethod and criteria for the diagnosis of this globally important disease. This review provides a comprehensive overview of the current issues surrounding how HbA1c is measured and reported; and of the evidence for and against itsuse indiagnosis.