期刊
JOURNAL OF INTERNAL MEDICINE
卷 271, 期 4, 页码 353-365出版社
WILEY
DOI: 10.1111/j.1365-2796.2012.02511.x
关键词
clinical application; genetic variation; genome-wide association studies; prostate cancer; risk modelling; single nucleotide polymorphism
资金
- NIH [1 U19 CA 148537-01]
- Cancer Research UK [15007, 13232] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10096] Funding Source: researchfish
- Prostate Cancer UK [G2011/36] Funding Source: researchfish
Prostate cancer is the commonest cancer in the developed world. There is an inherited component to this disease as shown in familial and twin studies. How-ever, the discovery of these variants has been difficult. The emergence of genome-wide association studies has led to the identification of over 46 susceptibility loci. Their clinical utility to predict risk, response to treatment, or treatment toxicity, remains undefined. Large consortia are needed to achieve adequate statistical power to answer these genetic clinical and genetic-epidemiological questions. International collaborations are currently underway to link genetic with clinical / epidemiological data to develop risk prediction models, which could direct screening and treatment programs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据