Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study

Lin C-H, Sheu WH-H (Taichung Veterans General Hospital; Taichung Veterans General Hospital; Chung Shan Medical University, Taichung; National Yang-Ming University, Taipei; and National Chung-Hsing University, Taichung, Taiwan). Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study. J Intern Med 2013; 273: 102-110. Objective We investigated the risk of dementia in patients with type 2 diabetes with or without prior hypoglycaemic episodes. Subjects and Setting One million subjects randomly selected from the National Health Insurance Research Database, Taiwan. Results A total of 15 similar to 404 diabetic subjects without prior dementia and a mean age of 64.2 similar to years were enrolled in the study. About 2% (n similar to=similar to 289) of participants had at least one episode of hypoglycaemia in a 3-year period; these subjects were older and more likely to be women and also had higher rates of insulin use and comorbidities compared to those without hypoglycaemia. During a total of 7 similar to years of follow-up (mean and median follow-up, 3.8 and 4.8 similar to years, respectively), 1106 patients with diabetes (7.2%) developed dementia. The incidence rate of dementia was higher in diabetic subjects with [29.9 per 1000 person-years (95% CI 22.139.2)] compared to those without [11.1 per 1000 person-years (95% CI 10.311.8)] hypoglycaemic episodes. The crude rate ratio (RR) and age- and gender-adjusted RR values for dementia were 2.76 (95% CI 2.063.70, P similar to