期刊
JOURNAL OF INTERNAL MEDICINE
卷 272, 期 5, 页码 440-448出版社
WILEY
DOI: 10.1111/j.1365-2796.2012.02587.x
关键词
gene-environment interaction; genome-wide association studies; missing heritability; obesity; physical activity; twin studies
资金
- Academy of Finland Center of Excellence in Complex Disease Genetics [213506, 129680]
- Academy of Finland [100499, 205585, 118555, 141054]
- Global Research Awards for Nicotine Dependence (GRAND)
- European Network for Genetic and Genomic Epidemiology (ENGAGE) [201413]
- NIH [DA12854, AA12502, AA00145, AA09203, AA15416]
Since 2006, the advent of increasingly larger genome-wide association studies and their meta-analyses have led to numerous, replicated findings of genetic polymorphisms associated with many diseases and traits. Early studies suggested that the identified loci generally accounted for a small fraction of the genetic variance estimated from twin and family studies. This led to the concept of missing heritability. Here, the progress in accounting for a greater proportion of the variance is reviewed. In particular, geneenvironment interactions can, for some traits and in certain circumstances, explain part of this missing heritability.
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