期刊
JOURNAL OF INTERNAL MEDICINE
卷 268, 期 5, 页码 501-510出版社
WILEY
DOI: 10.1111/j.1365-2796.2010.02267.x
关键词
adiposity; interleukin-6; leptin; lipids; vitamin D deficiency
资金
- National Health and Medical Research Council of Australia
- Arthritis Foundation of Australia
- Tasmanian Community Fund
- University of Tasmania
- Rising Star Program
- NHMRC
Ding C, Parameswaran V, Blizzard L, Burgess J, Jones G (Menzies Research Institute, University of Tasmania, Hobart, Tas.; Monash University, Melbourne, Vic.; Royal Hobart Hospital, Hobart, Tas., Australia). Not a simple fat soluble vitamin: changes in serum 25-(OH)D levels are predicted by adiposity and adipocytokines in older adults. J Intern Med 2010; 268: 501-510. Objective. To determine the associations between body adiposity and change in serum 25-(OH)D levels over 2.6 years, and if these associations are mediated by metabolic and inflammatory factors in older adults. Methods. This is a longitudinal study of 859 randomly selected subjects (mean 62 years, range 51-80, 49% women). Serum 25-hydroxyvitamin D [25-(OH)D] was assessed by radioimmunoassay at baseline and 2.6 years later. Baseline serum level of leptin was assessed by radioimmunoassay and interleukin (IL)-6 by a chemiluminescent immunoassay in the first 183 subjects. Results. In multivariable analyses, body mass index, trunk fat percentage and waist-to-hip ratio were significant predictors of increased incident vitamin D deficiency [a 25-(OH)D < 50 nmol L-1 at follow-up when >= 50 nmol L-1 at baseline] and decreased recovery of vitamin D deficiency [a 25-(OH)D >= 50 nmol L-1 at follow-up when < 50 nmol L-1 at baseline]. Change in 25-(OH)D levels per annum was also independently predicted by baseline leptin (beta: -0.09/unit, 95% CI: -0.17, -0.03), IL-6 (beta: -0.68/quartile, 95% CI: -1.35, -0.02) and total cholesterol/high-density lipoprotein (HDL) ratio (beta: -0.51, 95% CI: -0.88, -0.14). The associations between body adiposity measures and change in 25-(OH)D completely disappeared after adjustment for leptin, diminished after adjustment for IL-6, but remained unchanged after adjustment for total cholesterol/HDL ratio. All associations were independent of season and sun exposure. Conclusions. Body fat is not simply a passive reservoir for 25-(OH)D. In addition to season and sun exposure, 25-(OH)D levels appear to be determined by metabolic and, to a lesser extent, inflammatory factors, and these appear to mediate the effects of adiposity on change in 25-(OH)D.
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