期刊
JOURNAL OF INTERNAL MEDICINE
卷 269, 期 1, 页码 16-28出版社
WILEY
DOI: 10.1111/j.1365-2796.2010.02313.x
关键词
cytokines; diabetes; heart failure; inflammation
资金
- NIH [AI-15614, CA-04 6934, JDRF 26-2008-893]
- NATIONAL CANCER INSTITUTE [P30CA046934] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI015614, R37AI015614] Funding Source: NIH RePORTER
Dinarello CA (Department of Medicine, University of Colorado, Aurora, CO, USA). Blocking interleukin-1 beta in acute and chronic autoinflammatory diseases. (Key Symposium) J Intern Med 2011; 269: 16-28. An expanding spectrum of acute and chronic inflammatory diseases is considered 'autoinflammatory' diseases. This review considers autoinflammatory diseases as being distinct from 'autoimmune' diseases. Autoimmune diseases are associated with dysfunctional T cells and treated with 'biologicals', including antitumour necrosis factor alpha, CTLA-Ig, anti-IL-12/23, anti-CD20, anti-IL-17 and anti-IL-6 receptor. In contrast, autoinflammatory diseases are uniquely attributed to a dysfunctional monocyte caspase 1 activity and secretion of IL-1 beta; indeed, blocking IL-1 beta results in a rapid and sustained reduction in the severity of most autoinflammatory diseases. Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1 beta neutralization.
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