期刊
JOURNAL OF INTERNAL MEDICINE
卷 265, 期 1, 页码 110-124出版社
WILEY
DOI: 10.1111/j.1365-2796.2008.02041.x
关键词
elite controllers; exposed uninfected individuals; exposed-seronegative individuals; genetic correlates; HIV; long-term non progressors
资金
- Istituto Superiore di Sanita' 'Programma Nazionale di Ricerca sull' AIDS'
- EMPRO
- AVIP EC WP6 Projects
- nGIN
- GISHEAL EC WP7 Projects
- Japan Health Science Foundation
Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.
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