期刊
JOURNAL OF INTERNAL MEDICINE
卷 263, 期 5, 页码 489-499出版社
WILEY
DOI: 10.1111/j.1365-2796.2008.01944.x
关键词
atherosclerosis; cytokines; immunity; inflammation; lymphocytes
Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. Recent studies from several groups suggest that subtypes of T cells, called regulatory T cells, previously shown to maintain immunological tolerance, inhibit the development and progression of atherosclerosis. Here, we review the current knowledge on the regulatory T-cell response and the major cytokines involved in its modulation in the context of atherosclerosis.
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