期刊
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
卷 34, 期 4, 页码 289-296出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2013.0148
关键词
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资金
- NCI NIH HHS [T32 CA070085, R01 CA077816, R01 CA161796, P30 CA060553, R01 CA155566] Funding Source: Medline
Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.
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