期刊
OSTEOPOROSIS INTERNATIONAL
卷 27, 期 3, 页码 1199-1208出版社
SPRINGER LONDON LTD
DOI: 10.1007/s00198-015-3366-9
关键词
Aged 80 and over; Determinants; Newcastle 85+cohort study; Serum 25-hydroxyvitamin D
资金
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Dunhill Medical Trust
- Newcastle University
- North of England Commissioning Support Unit
- National Institute for Health Research Newcastle Biomedical Research Centre, at Newcastle upon Tyne Hospitals NHS Foundation Trust
- British Heart Foundation
- Unilever Corporate Research
- Medical Research Council [G0500997, G0500783, MR/K02325X/1, MR/K02325X/1B, G0700718B, G0700718, MR/K006312/1, MR/L016354/1, MR/J50001X/1] Funding Source: researchfish
- National Institute for Health Research [NIHR-RP-02-12-001, NF-SI-0508-10260] Funding Source: researchfish
- MRC [MR/K006312/1, MR/J50001X/1, G0500997, G0500783, MR/L016354/1, G0700718] Funding Source: UKRI
A Summary Data on vitamin D status in very old adults are lacking. The aim of this study was to assess 25-hydroxyvitamin D [25(OH)D] concentrations and its predictors in 775 adults aged 85 years old living in North-East England. Low 25(OH)D was alarmingly high during winter/spring months, but its biological significance is unknown. Introduction Despite recent concerns about the high prevalence of vitamin D deficiency in much of the British adult and paediatric population, there is a dearth of data on vitamin D status and its predictors in very old adults. The objective of the present study was to describe vitamin D status and its associated factors in a broadly representative sample of very old men and women aged 85 years living in the North East of England (55A degrees N). Methods Serum concentrations of 25-hydroxyvitamin D [25(OH)D] were analysed in 775 participants in the baseline phase of the Newcastle 85+ cohort study. Season of blood sampling, dietary, health, lifestyle and anthropometric data were collected and included as potential predictors of vitamin D status in ordinal regression models. Results Median serum 25(OH)D concentrations were 27, 45, 43 and 33 nmol/L during spring, summer, autumn and winter, respectively. The prevalence of vitamin D deficiency according to North American Institute of Medicine guidelines [serum 25(OH)D < 30 nmol/L] varied significantly with season with the highest prevalence observed in spring (51 %) and the lowest prevalence observed in autumn (23 %; P < 0.001). Reported median (inter-quartile range) dietary intakes of vitamin D were very low at 2.9 (1.2-3.3) mu g/day. In multivariate ordinal regression models, non-users of either prescribed or non-prescribed vitamin D preparations and winter and spring blood sampling were associated with lower 25(OH)D concentrations. Dietary vitamin D intake, disability score and disease count were not independently associated with vitamin D status in the cohort. Conclusion There is an alarming high prevalence of vitamin D deficiency (< 30 nmol/L) in 85-year-olds living in North East England at all times of the year but particularly during winter and spring. Use of vitamin D containing preparations (both supplements and medications) appeared to be the strongest predictor of 25(OH)D concentrations in these very old adults.
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