期刊
OSTEOARTHRITIS AND CARTILAGE
卷 23, 期 2, 页码 249-256出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2014.11.005
关键词
Inflammation; Weight loss; Total body fat mass; Regional fat mass; Osteoarthritis
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR052528]
- Wake Forest University Claude D. Pepper Older Americans Independence Center [P30-AG21332]
- Arthritis and Musculoskeletal Disease Research Center at Wake Forest School of Medicine
- Wake Forest School of Medicine Translational Science Institute
- Wake Forest University Science Research Fund
- Department of Health and Exercise Science
Objective: To describe associations between total and regional body fat mass loss and reduction of systemic levels of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in obese, older adults with osteoarthritis (OA), undergoing intentional weight loss. Design: Data come from a single-blind, 18-month, randomized controlled trial in adults (age: 65.6 +/- 6.2; Body mass index (BMI): 33.6 +/- 3.7) with knee OA. Participants were randomized to diet-induced weight loss plus exercise (D + E; n = 150), diet-induced weight loss-only (D; n = 149), or exercise-only (E; n = 151). Total body and region-specific (abdomen and thigh) fat mass were measured at baseline and 18 months. High-sensitivity CRP and IL-6 were measured at baseline, six and 18 months. Intervention effects were assessed using mixed models and associations between inflammation and adiposity were compared using logistic and mixed linear regression models. Results: Intentional total body fat mass reduction was associated with significant reductions in logadjusted CRP (beta = 0.06 (95% CI = 0.04, 0.08) mg/L) and IL-6 (beta = 0.02 (95% CI = 0.01, 0.04) pg/mL). Loss of abdominal fat volume was also associated with reduced inflammation, independent of total body fat mass; although models containing measures of total adiposity yielded the best fit. The odds of achieving clinically desirable levels of CRP (< 3.0 mg/L) and IL-6 (< 2.5 pg/mL) were 3.8 (95% CI = 1.6, 8.9) and 2.2 (95% CI = 1.1, 4.6), respectively, with 5% total weight and fat mass loss. Conclusions: Achievement of clinically desirable levels of CRP and IL-6 more than double with intentional 5% loss of total body weight and fat mass. Global, rather than regional, measures of adiposity are better predictors of change in inflammatory burden. (C) 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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