期刊
JOURNAL OF INSECT PHYSIOLOGY
卷 58, 期 12, 页码 1556-1561出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jinsphys.2012.09.009
关键词
Tenebrio molitor; Immunity; SSH; Antimicrobial peptides; Persistent infection
资金
- Scurfield bursary
- Royal Entomological Society's Outreach Fund
- Hessian Ministry of Science and Art via the LOEWE-research focus Insect Biotechnology
Understanding the evolutionary ecology of immune responses to persistent infection could provide fundamental insight into temporal dynamics or interactive mechanisms that could be co-opted for antibiotic treatment regimes. Additionally, identification of novel molecules involved in these processes could provide novel compounds for biotechnological development. The beetle Tenebrio molitor displays a high level of induced antimicrobial activity coincident with persistent immuno-resistant Staphylococcus aureus, and is the first invertebrate model for persistent infection. Here we present expressed sequence tags (ESTs) detected by suppression-subtraction hybridization of Tenebrio larvae after infection with S. aureus. Amongst others, we identified mRNAs coding for various oxidative enzymes and two antimicrobial peptides. These ESTs provide a foundation for mechanistic study of Tenebrio's immune system. (C) 2012 Elsevier Ltd. All rights reserved.
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