期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 133, 期 -, 页码 87-91出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2013.11.008
关键词
Iron-sulfur cluster; Transcription factor; Superoxide; Nitric oxide; Redox regulation
资金
- Grants-in-Aid for Scientific Research [23570136] Funding Source: KAKEN
All bacteria are continuously exposed to environmental and/or endogenously active oxygen and nitrogen compounds and radicals. To reduce the deleterious effects of these reactive species, most bacteria have evolved specific sensor proteins that regulate the expression of enzymes that detoxify these species and repair proteins. Some bacterial transcriptional regulators containing an iron-sulfur cluster are involved in coordinating these physiological responses. Mechanistic and structural information can show how these regulators function, in particular, how chemical interactions at the cluster drive subsequent regulatory responses. The [2Fe-2S] transcription factor SoxR (superoxide response) functions as a bacterial sensor of oxidative stress and nitric oxide (NO). This review focuses on the mechanisms by which SoxR proteins respond to oxidative stress. (C) 2013 Published by Elsevier Inc.
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