期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 134, 期 -, 页码 1-11出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2013.12.005
关键词
Ruthenium; Bcl-2; G-quadruplexes; DNA structures; Anticancer
资金
- National Natural Science Foundation of China [20871056, 21171070, 21371075]
- Planned Item of Science and Technology of Guangdong Province [c1011220800060, c1211220800571]
- Natural Science Foundation of Guangdong Province
- Fundamental Research Funds for the Central Universities
Two ruthenium(II) complexes (Ru-complexes) were synthesized and characterized in this study. The selectivity and ability of the complexes to interact with bcl-2 DNA were investigated here. It turned out that [Ru(ip)(3)]ClO4)2 center dot 2H(2)O (complex 1, ip = 1H-iminazole [4,5-f][1,10] phenanthroline) could induce and stabilize the formations of G-quadruplexes more effectively than [Ru(pip)(3)](ClO4)(2)center dot 2H(2)O (complex 2, pip = 2-phenylimidazo-[4,5-f][1,10]phenanthroline) did. Considering the important role of the Ru-complex ligand in inducing and stabilizing the formations of G-quadruplex in our previous studies, we speculate that the overlarge ligand of complex 2 may block its binding affinity for G-quadruplexes. Complex 1 also induced cell apoptosis in in vitro assays. In general, this study provided potentially important information for further development of the Ru-complexes as good inducers and stabilizers of bcl-2 G-quadruplex DNA for cancer treatment Crown Copyright (c) 2014 Published by Elsevier Inc. All rights reserved.
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