期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 133, 期 -, 页码 127-135出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2013.10.015
关键词
Carbon monoxide; Therapeutics; Cytoprotective agents; Metal carbonyl complexes; Photoactive; CO delivery
资金
- NSF [CHE-0957251, DMR-1105296]
- IMSD [GM-58903]
- Direct For Mathematical & Physical Scien [1105296, 0957251] Funding Source: National Science Foundation
- Division Of Chemistry [0957251] Funding Source: National Science Foundation
- Division Of Materials Research [1105296] Funding Source: National Science Foundation
The surprising discovery of carbon monoxide (CO) as a signaling molecule in mammalian physiology has recently raised interest in this toxic gas among researchers in biochemical and pharmaceutical community. CO is endogenously produced mainly from catabolism of heme by the enzyme heme oxygenase (HO) and participates in a myriad of anti-inflammatory, anti-proliferative, and vasoregulatory pathways. In animal models, low doses of CO have exhibited beneficial effects in suppression of organ graft rejection and safeguarding the heart during re-perfusion after cardiopulmonary bypass surgery. The salutary effects of CO have naturally drawn attention of the pharmaceutical industry for its use as a cytoprotective agent. Safety-related concerns of the use of this noxious gas have prompted research in the area of syntheses of CO-releasing molecules (CORMs) and to date, several metal carbonyls (metal complexes of CO) have been employed as CORMs in promoting prolonged (and safe) delivery of low doses of CO to cellular targets. Because many carbonyl complexes release CO upon illumination, investigators have recently began to explore the possibility of controlled CO delivery through the use of light. During the past few years, a number of photoactive CORMs or photoCORMs have been synthesized that release CO upon illumination with UV or visible light. The utility of these photoCORMs in CO delivery has also been confirmed. Novel design principles for isolation of photoCORMs have started to appear in recent reports. Scrutiny of the literature reveals the emergence of a new exciting area of drug development in such efforts. The potential of photoCORMs as CO-donating pharmaceuticals along with a brief overview of the physiological roles of CO is presented in this review. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据