期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 126, 期 -, 页码 35-37出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2013.05.007
关键词
Aluminum sulfate; Alzheimer's disease; Endothelial cells; Genotoxicity; Human brain microvessel endothelial cells; Inflammation
资金
- NIA [P50 AG16573]
- National Center for Research Resources (NCRR) [P20RR016456]
- Translational Research Initiative (TRI) Grants from LSU Health Sciences Center New Orleans
- Alzheimer Association [IIRG-09-131729]
- NIH NIA [AG18031, AG038834]
Once biologically available aluminum bypasses gastrointestinal and blood-brain barriers, this environmentally-abundant neurotoxin has an exceedingly high affinity for the large pyramidal neurons of the human brain hippocampus. This same anatomical region of the brain is also targeted by the earliest evidence of Alzheimer's disease (AD) neuropathology. The mechanism for the selective targeting and transport of aluminum into the hippocampus of the human brain is not well understood. In an effort to improve our understanding of a pathological aluminum entry system into the brain, this study examined the aluminum content of 8 arteries that supply blood to the hippocampus, including the aorta and several cerebral arteries. In contrast to age-matched controls, in AD patients we found a gradient of increasing aluminum concentration from the aorta to the posterior cerebral artery that supplies blood to the hippocampus. Primary cultures of human brain endothelial cells were found to have an extremely high affinity for aluminum when compared to other types of brain cells. Together, these results suggest for the first time that endothelial cells that line the cerebral vasculature may have biochemical attributes conducive to binding and targeting aluminum to selective anatomical regions of the brain, such as the hippocampus, with potential downstream pro-inflammatory and pathogenic consequences. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据