期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 118, 期 -, 页码 134-139出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2012.10.008
关键词
Ring substituents; Piloty's acid; Azanone donors; Nitroxyl donors
资金
- UBA [UBACYT W583]
- FONCyT [PICT 2010-2649]
- CONICET [PIP 112-201001-00125]
- [PME-2006-01113]
A group of Piloty's acid (N-hydroxybenzenesulfonamide) derivatives were synthesized and fully characterized in order to assess the rates and pH of HNO (azanone, nitroxyl) donation in aqueous media. The derivatives, with electron-withdrawing and -donating substituents include methyl, nitro, fluoro, tri-isopropyl, trifluoromethyl and methoxy groups. The most interesting modulation observed is the change in pH range in which the compounds are able to donate HNO. UV-visible kinetic measurements at different pH values were used to evaluate the decomposition rate of the donors. A novel technique based on electrochemical measurements using a Co-porphyrin sensor was used to assess the release of HNO as a function of pH, by direct measurement of [HNO]. The results were contrasted with DFT calculations in order to understand the electronic effects exerted by the ring substituents, which drastically modify the pH range of donation. For example, while Piloty's acid donates HNO from pH 93, the corresponding fluoro derivative starts donating at pH 4.0. (C) 2012 Elsevier Inc. All rights reserved.
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