期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 117, 期 -, 页码 367-373出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2012.06.012
关键词
Silver nanoparticles; Drug delivery; Tetracycline hydrochloride; Hydrogel; Antibacterial effect
资金
- PNU
- INSF
In the present study, we report a facile and eco-friendly method for the preparation of a novel silver nanocomposite hydrogel (SNH) based on poly(acrylic acid) (PM) grafted onto salep as a water soluble polysaccharide backbone. The presence of inorganic silver nanoparticles (nano-Ag) in the hydrogel was confirmed by thermo-gravimetric (TG) analysis. The TEM images illustrated the presence of embedded nano-Ag throughout the hydrogel matrix. In addition, the transmission electron microscopy (TEM) images showed that the formed nano-Ag had an average particle size of 5-10 nm. The potential of obtained SNH was examined for Tetracycline hydrochloride (TH) release in simulated colon conditions. Lastly, the in vitro antibacterial properties of the obtained optimum sample were successfully evaluated against gram-negative and gram-positive bacteria. (C) 2012 Elsevier Inc. All rights reserved.
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