期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 112, 期 -, 页码 39-48出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2012.02.034
关键词
Oxidovandium complexes; DNA-binding; Cleavage; Antitumor
资金
- Guangdong Pharmaceutical University [43540119]
- National Key Research Project of China [2011zx09102-001-31]
- National Natural Science Foundation of P. R. China [81102753, 21101033]
Four oxidovanadium(IV) complexes, [VO(hntdtsc)(phen)] (1), [VO(hntdtsc)(bpy)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone, phen=1,10-phenanthroline), [VO(satsc)(phen)] (3) and [VO(satsc)(bpy)] (4) (satsc= salicylaldehyde thiosemicarbazone, bpy=2,2'-bipyridine) have been synthesized and characterized. The results show that complexes 1, 2, 3 and 4 interact with DNA through intercalative mode and can efficiently cleave the plasmid pBR 322 DNA. It is interesting to note that these four complexes present highly cytotoxic activities against Myeloma cell (Ag8.653) and Gliomas cell (U251) lines. Complex 1 was found to be the most potent antitumor agent among the four complexes. (C) 2012 Elsevier Inc. All rights reserved.
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