4.6 Article

Comparison of the SOD-like activity of hexacoordinate Mn(II), Fe(II) and Ni(II) complexes having isoindoline-based ligands

期刊

JOURNAL OF INORGANIC BIOCHEMISTRY
卷 105, 期 6, 页码 911-918

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2011.01.016

关键词

Mn-SOD; Manganese(II) complexes; Ni(II) complexes; SOD-like activity; Isoindoline ligand; Redox chemistry

资金

  1. Hungarian National Research Fund [OTKA K67871, OTKA K75783, OTKA PD75360]
  2. Budaconsum Ltd.
  3. TET
  4. COST

向作者/读者索取更多资源

Recently, a series of Fe(II) complexes have been published by our group with 3 N-donor 1,3-bis(2'-Ar-imino) isoindoline ligands containing various Ar-groups (pyridyl, 4-methylpyridyl, thiazolyl, benzimidazolyl and N-methylbenzimidazolyl). The superoxide scavenging activity of the compounds showed correlation with the Fe(III)/Fe(II) redox potentials. Analogous, electroneutral chelate complexes with Mn(II) and Ni(II) in 2:1 ligand: metal composition are reported here. Each Mn(II) complex exhibits one reversible redox wave that is assigned as the Mn(III)/Mn(II) redox transition. The E-1/2 spans a 180 mV range from -98 (Ar = 3-methylpyridyl) to 82 mV (Ar = thiazolyl) vs. the Fc(+)/Fc depending on the Ar-sidearm. The SOD-like (SOD = superoxide dismutase)activity of all complexes was determined according to the McCord-Fridovich method. The Mn(II) isoindolinates have IC50 values - determined with 50 mu M cytochrome c Fe(III) - that range from (3.22 +/- 0.39) x 10(-6) (Ar = benzimidazolyl) to (10.80 +/- 0.54) x 10(-6) M (Ar = N-methylbenzimidazolyl). In contrast with the Fe(II) complexes, the IC50 concentrations show no significant dependence on the E-1/2 values in this narrow potential range emphasizing that the redox potential is not the governing factor in the Mn(II)-containing scavengers. The analogous Ni(II) compounds show no redox transitions in the thermodynamically relevant potential range (-0.40 to 0.65 V vs. SCE) and accordingly, their superoxide scavenging activity (if any) is below the detection level. (C) 2011 Elsevier Inc. All rights reserved.

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