期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 104, 期 6, 页码 625-631出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2010.02.003
关键词
Gold; Phosphine; Lipophilic-cationic complexes; X-ray crystallography; Cytotoxicity
资金
- Griffith University
- Queensland University of Technology
- Eskitis Institute for Cell and Molecular Therapies
- Queensland Institute of Medical Research
Four-coordinate 1:2 gold(I) complex salts with cis-bis(diphenylphosphino)ethene, [Au(dppey)(2)]X have been synthesized for X = PF6-, CF3SO3-, BF4-, Cl-, Br- and BPh4- and characterized by NMR spectroscopy and electrospray mass spectrometry. Single crystal X-ray structure determinations show the BE4-, Cl- and Br- complexes to be isostructural, although with different degrees of hydration, while the BPh4- complex crystallizes as an acetone solvate with two molecules in the asymmetric unit. The Au(P-P)(2) core for the BET, Cl- and Br- complexes adopts D-2 symmetry with Au-P bond lengths 2.3980(7)-2.4009(7) angstrom and inter-ligand P-Au-P angles 114.78(2)-127.82(2))degrees. The Au(P-P)(2) core in the BPh4- complex is unsymmetrical with Au-P bond lengths 2.364(1)-2.420(1) angstrom and inter-ligand P-Au-P angles 104.76(5)-137.50(4)degrees. In vitro cytotoxicity studies show the PF6-, CF3SO3-, BF4-, Cl-, Br- and I- complexes to be potent and selective growth inhibitors of the human cell lines MCF7 (hormone-dependent breast cancer), MDA-MB-231 (hormone-independent breast cancer), MM96L (melanoma), CI80-13S (cisplatin resistant ovarian cancer) and a normal cell line NFF (neonatal foreskin fibroblasts), achieving IC50 values between 13 and 196 nM. The halogen and triflate salts were approximately twice as potent towards the MCF7 and MDA-MB-231 cell lines compared to the PF6- and BF4- derivatives; while the cytotoxicity of all complexes towards the sensitive CI80-13S and MM96L cancer cell lines was approximately 10-fold greater than that displayed towards the normal human cell line (NFF). (C) 2010 Elsevier Inc. All rights reserved.
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