期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 103, 期 3, 页码 396-400出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2008.12.001
关键词
Rare earth complexes; Curcumin; 1,10-Phenanthroline-5,6-dione; Antibacterial activity
资金
- Key Laboratory of Eco-Environment-Related Polymer Materials (Northwest Normal University)
- Ministry of Education of China and Gansu Province [0710JRZA108]
Three new solid complexes have been synthesized by the reaction of rare earth(III) nitrate with the first ligand curcumin (HL) and the second ligand 1,10-phenanthroline-5,6-dione (L') in alcohol solution (pH = 6.5-7.0). The composition of the complexes has been characterized by elemental analysis, molar conductivity, thermogravimetric analysis, IR, UV-vis methods. The results reveal that beta-diketone group of the first ligand to coordinates with rare earth ions in bidentate mode after deprotonated. But the second ligand uses its two N atoms coordinates with rare earth ions in bidentate mode. The general formula of the complexes is REL3L' (RE = Sm, Eu, Dy). The results of antibacterial activity indicated that the complexes have excellent antibacterial ability for the testing bacterium than that of curcumin. The result of agarose gel electrophoresis suggested that the complex of SmL3L' can cleave the plasmid DNA at physiological pH and temperature. And it was found that the cleavage process of plasmid DNA was sensitive to pH, however, adding radical scavengers almost had no effect on the DNA cleavage reaction, therefore, the cleavage of DNA by SmL3L' does not produce diffusible hydroxyl radicals via the Fenton reaction. (C) 2008 Published by Elsevier Inc.
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