期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 103, 期 3, 页码 373-380出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2008.11.014
关键词
Drug delivery; Anionic dendrimer; Platinum(II); Ruthenium(II); Nuclear magnetic resonance
资金
- School of Biomedical and Health Sciences New Project Develop Grant (UWS)
The use of anionic half-generation poly(amidoamine) dendrimers as drug delivery vehicles for [Pt(S,S-dach)(5,6- Me(2)phen)](2+) (56MESS) (where S,S-dach = 1S,2S-diaminocyclohexane: 5,6-Me(2)phen=5,6-dimethyl-1,10-phenanthroline) and [{Lambda,Lambda-Ru(phen)(2)}(2)(mu-bb7)](4+) (Rubb(7)) (where phen = 1,10-phenanthroline; bb7 = 1,7-bis[4-(4'-methyl-2,2'-bipyridyl)heptane]) has been studied by nuclear magnetic resonance spectroscopy. From one- and two-dimensional H-1 NMR spectra both 56MESS and Rubb(7) were found to bind to the Surface of generation 3.5, 4.5, 5.5 and 6.5 dendrimers through electrostatic interactions. The higher charge and larger size of Rubb(7) resulted in stronger binding to all dendrimer generations (K-b >= 2 x 10(5) M (1)) compared with 56MESS (K-b >= 1 X 10(4) M-1). Interestingly, there appeared to be no observable trend between dendrimer size and binding constant strength. The size of the free and 56MESS-bound dendrimers were examined using pulsed-gradient spin-echo NMR. The dendrimers ranged in hydrodynamic diameter from 11 to 20 nm and in all cases were larger than their corresponding full-generation dendrimer. Upon the addition of 56MESS the diameter of the dendrimers increased, consistent with surface binding. (C) 2008 Elsevier Inc. All rights reserved.
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