期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 103, 期 7, 页码 1074-1081出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2009.05.004
关键词
Desferrioxamine; Caco2 cell; Anti-proliferation; Apoptosis; Mitochondria
资金
- Hong Kong Research Grants Council Grant [HKU7512/05]
- Chang-Jiang Scholars Program
- National Natural Science Foundation of China [20871057, 20801061]
- Talents Start-up Foundation of Jinan University [JNU51208047]
Iron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion. (C) 2009 Elsevier Inc. All rights reserved.
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