期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 103, 期 3, 页码 313-315出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2008.11.005
关键词
P450 monooxygenases; Cytochrome C; Peroxide shunt pathway; Direct regeneration
资金
- ETH research [TH 24199-3]
The organometallic complex pentamethylcyclopentadienyl rhodium 2,2'-bipyridin ([Cp*Rh(bpy)(H2O)](2+)) was applied as regeneration catalyst for cytochrome C (CytC). Direct reduction of CytC-bound Fe was achieved in this model system pointing towards a potential usefulness of this concept to promote cell-free P450 catalysis. In addition, controlled in situ provision with hydrogen peroxide was performed using [Cp*Rh(bpy)(H2O)](2+) resulting in improved CytC-catalyzed sulfoxidation of thioanisol This work represents the first step towards the direct-[Cp*Rh(bpy)(H2O)](2+) catalyzed regeneration of P450 monooxygenases and peroxidases. (C) 2008 Elsevier Inc. All rights reserved.
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