期刊
JOURNAL OF INNATE IMMUNITY
卷 6, 期 2, 页码 169-181出版社
KARGER
DOI: 10.1159/000353602
关键词
Anopheles; Innate immunity; Plasmodium; Malaria; Mosquito
类别
资金
- National Institutes of Health/National Institute of Allergy and Infectious Disease
- UNCF-Merck Science Initiative Graduate Research Fellowship
- Bloomberg Family Foundation
The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection. Copyright (C) 2013 S. Karger AG, Basel
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