期刊
JOURNAL OF INNATE IMMUNITY
卷 4, 期 4, 页码 337-348出版社
KARGER
DOI: 10.1159/000336619
关键词
Antimicrobial peptides; Host defense; Toll-like receptor; Defensin
类别
资金
- Medical Research Council [MC_PC_U127527201] Funding Source: researchfish
- MRC [MC_PC_U127527201] Funding Source: UKRI
Defensins comprise one of the largest groups of host defence peptides, present throughout evolution, in fungi and flowering plants as well as in invertebrates and vertebrates. These cysteine-rich, cationic peptides have a common ability to kill a broad range of microorganisms including bacteria, yeast and viruses. As such, they are a strong component of the arsenal that is an organism's innate immunity. It is becoming increasingly clear, however, that antimicrobial action is only one of the numerous roles of these multifunctional peptides. In recent years, the functions of defensins in immunomodulation have been widely investigated, and their involvement in other processes (such as fertility) is becoming evident. This review addresses recent advances in the immunonnodulatory activity of beta-defensins as well as the involvement of beta-defensins in fertility, development, wound healing and cancer. Copyright (C) 2012 S. Karger AG, Basel
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