期刊
JOURNAL OF INNATE IMMUNITY
卷 4, 期 5-6, 页码 509-528出版社
KARGER
DOI: 10.1159/000339153
关键词
Drug delivery; Macrophage diseases; Nanomedicine; Nanoparticles; Phagocytosis
类别
资金
- Danish Agency for Science, Technology and Innovation (Det Strategiske Forskningsrad) [2106-08-0081]
- Faculty of Health and Medical Sciences, University of Copenhagen
Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physicochemical properties, which include hydrodynamic size, shape, composition and surface characteristics. Through such modifications together with understanding of macrophage cell biology, targeting may be aimed at a particular subset of macrophages. Advances in basic and therapeutic concepts of particulate targeting of rnacrophages and related nanotechnology approaches for immune cell modifications are discussed. Copyright (C) 2012 S. Karger AG, Basel
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