期刊
JOURNAL OF INNATE IMMUNITY
卷 1, 期 5, 页码 413-420出版社
KARGER
DOI: 10.1159/000226256
关键词
Antimicrobial peptides; Defensins; Infectious diseases; Viruses; Virus-host cell interactions
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI081559] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI081559] Funding Source: Medline
Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses. The effects of defensins on viral infections appear to be specific to the defensin, virus and target cell. Regulation of viral infection by defensins is achieved by multiple mechanisms. This review focuses on the interplay between defensins and viral infections, the mechanisms of action of defensins and the in vivo studies of the role of defensins in viral infections. Copyright (C) 2009 S. Karger AG, Basel
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