期刊
JOURNAL OF INNATE IMMUNITY
卷 1, 期 2, 页码 123-135出版社
KARGER
DOI: 10.1159/000163037
关键词
Mucin; Innate immunity; Inflammatory bowel disease; Toll-like receptors
类别
资金
- Canadian Institute for Health Research
- Crohn's and Colitis Foundation of Canada
- Canadian Foundation for Innovation
- Natural Sciences and Engineering Research Council of Canada
- Canadian Association of Gastroenterology-Astra Zeneca-CIHR
Gastrointestinal mucins produced by goblet cells comprise the main structural components of the mucus layer. Mucins play a critical role in the maintenance of mucosal homeostasis and are responsible for the differential effector and regulatory responses against a plethora of microorganisms, including commensals and pathogens. In this review, we present a comprehensive overview on mucin biology, its properties, classification and gene assembly. We also consider the structure of the mucin gene, its proteins and its role in innate host defenses. We compare the various mucin secretagogues and the differential regulatory pathways involved in mucin biosynthesis and secretion during normal and diverse pathogenic conditions. Finally, we summarize the putative uncharted aspects of mucin-derived innate host defenses, whose exploration will help drug developers to identify factors that can strengthen mucosal integrity and will facilitate basic science research into curative treatments for gastrointestinal diseases. Copyright (C) 2008 S. Karger AG, Basel
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