期刊
JOURNAL OF INFECTIOUS DISEASES
卷 210, 期 4, 页码 651-655出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu176
关键词
HIV; medroxyprogesterone acetate; vaginal mucosa
资金
- National Institute of Child Health and Human Development
- National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) [R01HD033203, UM1AI068618]
- NIAID, NIH [1K08AI087969-01]
Background. Depot medroxyprogesterone acetate (DMPA) has been linked to human immunodeficiency virus type 1 (HIV-1) acquisition. Methods. Vaginal microbiota of women using DMPA for up to 2 years were cultured. Mucosal immune cell populations were measured by immunohistological staining. Results. Over 12 months, the proportion with H2O2-positive lactobacilli decreased (n = 32; 53% vs 27%; P = .03). Median vaginal CD3(+) cells also decreased (n = 15; 355 vs 237 cells/mm(2); P = .03), as did CD3(+)CCR5(+) cells (195 vs 128 cells/mm(2); P = .04), HLA-DR+ cells (130 vs 96 cells/mm(2); P = .27), and HLA-DR+ CCR5(+) cells (18 vs 10 cells/mm(2); P = .33). Conclusions. DMPA contraception does not increase vaginal mucosal CCR5(+) HIV target cells but does decrease CD3(+) T lymphocytes and vaginal H2O2-producing lactobacilli.
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