期刊
JOURNAL OF INFECTIOUS DISEASES
卷 210, 期 11, 页码 1792-1799出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu327
关键词
acute respiratory illnesses; influenza; respiratory viruses; households with children; surveillance
资金
- National Institute of Allergy and Infectious Diseases [R01 AI097150]
- Centers for Disease Control and Prevention [U01 IP000474]
Background. The household has traditionally been the site for studying acute respiratory illnesses (ARIs). Most studies were conducted many years ago, and more broadly sensitive laboratory methods to determine ARI etiology are now available. Methods. We recruited and followed households with children over 3 annual surveillance periods and collected respiratory tract specimens from subjects with reported ARI. Virus etiology was determined by real-time reverse-transcription polymerase chain reaction (RT-PCR) analysis. Results. Individuals in larger households (defined as households with > 4 members) and those in households with children aged < 5 years had significantly higher ARI frequencies than others. ARI frequency generally declined with increasing age. Virus etiology was most likely to be determined in young children, who were also most likely to have virus coinfection. Overall, 16% of ARIs with 1 virus identified had a parts per thousand yen1 coinfecting virus. Rhinoviruses and coronaviruses were the most frequently identified agents of ARI in all age categories. Influenza virus and adenovirus were less frequently identified but were most likely to cause ARI that required medical attention. Conclusions. Longitudinal studies in families remain a valuable way to study respiratory infections. RT-PCR has increased the sensitivity of virus detection, including coinfecting viruses, and expanded our ability to detect viruses now known to cause ARI.
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