期刊
JOURNAL OF INFECTIOUS DISEASES
卷 210, 期 9, 页码 1367-1375出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu274
关键词
Yersiniosis; plague; Yersinia; innate immunity; two-component systems; polymorphonuclear leukocyte
资金
- Institut National de la Sante et de la Recherche Medicale
- Institut Pasteur de Lille
- Universite Lille Nord de France
- Centre National de la Recherche Scientifique
- Region Nord Pas de Calais
- European Regional Development Fund as part of the Action de recherche concertee d'initiative regionale program [10090077-Presage 35712]
- European Community (ERC-STG INTRACELLTB grant) [260901]
- Agence Nationale de Recherche
- Feder ([D-AL] Equipex Imaginex BioMed-Bioimaging Center of Lille) [12001407]
- Direction Generale de l'Armement
- Fondation pour la Recherche Medicale
- European Research Council (ERC) [260901] Funding Source: European Research Council (ERC)
Plague is transmitted by fleas or contaminated aerosols. To successfully produce disease, the causal agent (Yersinia pestis) must rapidly sense and respond to rapid variations in its environment. Here, we investigated the role of 2-component regulatory systems (2CSs) in plague because the latter are known to be key players in bacterial adaptation to environmental change. Along with the previously studied PhoP-PhoQ system, OmpR-EnvZ was the only one of Y. pestis' 23 other 2CSs required for production of bubonic, septicemic, and pneumonic plague. In vitro, OmpR-EnvZ was needed to counter serum complement and leukocytes but was not required for the secretion of antiphagocyte exotoxins. In vivo, Y. pestis lacking OmpR-EnvZ did not induce an early immune response in the skin and was fully virulent in neutropenic mice. We conclude that, throughout the course of Y. pestis infection, OmpR-EnvZ is required to counter toxic effectors secreted by polymorphonuclear leukocytes in the tissues.
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