期刊
JOURNAL OF INFECTIOUS DISEASES
卷 211, 期 7, 页码 1087-1096出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu575
关键词
Plasmodium falciparum; outbreak; epidemic; drug resistance; molecular surveillance; tropical diseases
资金
- SENACYT-IFHARU
- Ministerio de Economia y Finanzas de Panama-Gorgas Memorial Institute of Health Studies
- International Centers of Excellence for Malaria Research, National Institute of Allergy and Infectious Diseases [5U19AI089702]
- Bill and Melinda Gates Foundation [OPP1053604]
- National Institutes of Health [R01A1077558]
- Bill and Melinda Gates Foundation [OPP1053604] Funding Source: Bill and Melinda Gates Foundation
Identifying the source of resurgent parasites is paramount to a strategic, successful intervention for malaria elimination. Although the malaria incidence in Panama is low, a recent outbreak resulted in a 6-fold increase in reported cases. We hypothesized that parasites sampled from this epidemic might be related and exhibit a clonal population structure. We tested the genetic relatedness of parasites, using informative single-nucleotide polymorphisms and drug resistance loci. We found that parasites were clustered into 3 clonal subpopulations and were related to parasites from Colombia. Two clusters of Panamanian parasites shared identical drug resistance haplotypes, and all clusters shared a chloroquine-resistance genotype matching the pfcrt haplotype of Colombian origin. Our findings suggest these resurgent parasite populations are highly clonal and that the high clonality likely resulted from epidemic expansion of imported or vestigial cases. Malaria outbreak investigations that use genetic tools can illuminate potential sources of epidemic malaria and guide strategies to prevent further resurgence in areas where malaria has been eliminated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据